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Kosmoliaptsis Research Group

  1. Maguire C, Crivello P, Fleischhauer K, Isaacson D, Casillas A, Kramer CSM, Copley HC, Heidt S, Kosmoliaptsis V, Meneghini M, Gmeiner M, Schold J, Louzoun Y, Tambur AR. Qualitative, rather than quantitative, differences between HLA-DQ alleles affect HLA-DQ immunogenicity in organ transplantation. HLA. 2024; 103: e15455. doi: 10.1111/tan.15455
  2. Senev A, Tambur AR, Kosmoliaptsis V, Copley HC, Garcia-Sanchez C, Usenko C, Ildstad ST, Leventhal J. HLA molecular mismatches and induced donor-specific tolerance in combined living donor kidney and hematopoietic stem cell transplantation. Front Immunol. 2024; 15: 1377535. doi: 10.3389.
  3. Priddey A, Chen-Xu MXH, Cooper DJ, MacMillan S, Meisl G, Xu CK, Hosmillo M, Goodfellow IG, Kollyfas R, Doffinger R, Bradley JR, Mohorianu II, Jones R, Knowles TPJ, Smith R, Kosmoliaptsis V. Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy. Front Immunol. 2024 Jan 8;14:1296148.
  4. Kim JJ, Curtis RMK, Reynolds B, Marks SD, Drage M, Kosmoliaptsis V, Dudley J, Williams A. The UK kidney donor risk index poorly predicts long-term transplant survival in paediatric kidney transplant recipients. Front Immunol. 2023 June 02; 14: 1207145
  5. Kim JJ, Fichtner A, Copley HC, Gragert L, Süsal C, Strologo LD, Oh J, Pape L, Weber LT, Weitz M, König J, Krupka K, Tönshoff B, Kosmoliaptsis V. Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation. Front Immunol. 2023 Mar 24;14:1188527
  6. Schneider MM*, Scheidt T*, Priddey AJ*, Xu CK*, Hu M, Meisl G, Devenish SRA, Dobson CM, Kosmoliaptsis V*, Knowles TPJ*. Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum. Biosensors and Bioelectronics 2023; 228: 115196
  7. Spiers HVM, Stadler LKJ, Smith H, Kosmoliaptsis V. Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier. Pharmaceutics. 2023 Mar 9;15(3):891
  8. Balakrishnan A, Barmpounakis P, Demiris N, Jah A, Spiers HVM, Talukder S, Martin JL, Gibbs P, Harper SJF, Huguet EL, Kosmoliaptsis V, Liau SS, Praseedom RK, Basu B, de Aretxabala X, Lendoire J, Maithel S, Branes A, Andersson B, Serrablo A, Adsay V; OMEGA Study Investigators. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study. EClinicalMedicine. 2023; 59: 101951
  9. Tambur AR, Bestard O, Campbell P, et al (alphabetical). Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report. Am J Transplant.2023;23: 133
  10. Wu X, Senanayake R, Goodchild E, et al. [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nature Medicine 2023; 29: 190-202
  11. Watson CJE, MacDonald S, Bridgeman C, Brais R, Upponi SS, Foukaneli T, Swift L, Fear C, Selves L, Kosmoliaptsis V, Allison M, Hogg R, Parsy KS, Thomas W, Gaurav R, Butler AJ. D-dimer Release From Livers During Ex Situ Normothermic Perfusion and After In Situ Normothermic Regional Perfusion: Evidence for Occult Fibrin Burden Associated With Adverse Transplant Outcomes and Cholangiopathy. Transplantation. 2023 Jan 6. doi: 10.1097
  12. Emmenegger M, De Cecco E, Lamparter D, et al. Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region. iScience. 2023; 26: 105928
  13. Isaacson D, Schold JD, Gmeiner MW, Copley HC, Kosmoliaptsis V*, Tambur AR*. HLA-DQ Mismatches Lead to More Unacceptable Antigens, Greater Sensitization, and Increased Disparities in Repeat Transplant Candidates. J Am Soc Nephrol. 2022; 33: 2293
  14. Gaurav R, Butler AJ, Kosmoliaptsis V, Mumford L, Fear C, Swift L, Fedotovs A, Upponi S, Khwaja S, Richards J, Allison M, Watson CJE. Liver transplantation outcomes from controlled circulatory death donors: Static cold storage vs in situ normothermic regional perfusion vs ex situ normothermic machine perfusion. Annals of Surgery 2022; 275: 1156
  15. Lim WH, Ho J, Kosmoliaptsis V, Sapir-Pichhadze R. Future challenges and directions in determining allo-immunity in kidney transplantation. Front Immunol. 2022; 13: 1013711
  16. Fiedler S, Devenish SRA, Morgunov AS, et al. Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration. Scientific reports 2022; 12(1):19791
  17. Urquhart C, Flemming B, Harper I, Aloj L, et al. The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: a case report and literature review. Frontiers in Endocrinology 2022; 3: 1066208
  18. Wiebe C, Nickerson PW, Kosmoliaptsis V. Molecular Mismatch and the Risk for T Cell-Mediated Rejection. Am J Kidney Dis. 2022: 80(6):704-706
  19. Senev, A., Lerut, E., Coemans, M., Callemeyn, J., Copley, H. C., Claas, F., . . . Naesens, M. Association of HLA Mismatches and Histology Suggestive of Antibody-Mediated Injury in Absence of Donor-Specific Anti-HLA Antibodies. Clin J Am Soc Nephrol. 2022; 17: 1204
  20. Ashcroft J, Leighton P, Elliot TR, Hosgood SA, Nicholson ML, Kosmoliaptsis V. Extracellular Vesicles in Kidney Transplantation: A State of the Art Review. Kidney International 2022; 101: 485
  21. Denninger V, Xu CK, Meisl G, et al. Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2. ACS Infect Dis 2022; 8: 790-799
  22. Zou J, Kongtim P, Oran B, Kosmoliaptsis V, Carmazzi Y, Ma J, Li L, Rondon G, Srour S, Copley HC, Partlow D, Ciurea SO, Greenbaum U, Ma Q, Shpall EJ, Champlin RE, Cao K. Refined HLA-DPB1 mismatch with molecular algorithms predicts outcomes in hematopoietic stem cell transplantation. Haematologica 2022; 107: 844
  23. Balakrishnan A, Jah A, Lesurtel M, et al. Heterogeneity of management practices surrounding operable gallbladder cancer - results of the OMEGA-S international HPB surgical survey. HPB 2022: 2006-2012
  24. Tseretopoulou X, Murray MJ, Buck J, Hook CE, Jackson C, Kosmoliaptsis V, Hughes J, Gorman S, Williams RM. Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor. J Pediatr Hematol Oncol. 2022; 44: e736
  25. Lim WH et al (alphabetical authorship). Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants: protocol for the INCEPTION study. BMC Nephrology 2021; 19: 416
  26. Copley HC, Gragert L, Leach AR, Kosmoliaptsis V. Influence of HLA class II polymorphism on predicted cellular immunity against SARS-CoV-2 at the population and individual level. Frontiers in Immunology 2021; 12: 669357
  27. Schneider MM, Emmenegger M, Xu CK, Morales IC, Meisl G, Turelli P, Zografou C, Zimmermann MR, Frey BM 4, Fiedler S, Denninger V, Jacquat  R, Madrigal L, Ilsley A, Kosmoliaptsis V, Fiegler H, Trono D, Knowles TP, Aguzzi A. Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma. Life Sci Alliance 2021; 30: e202101270
  28. Tambur AR, Kosmoliaptsis V, Claas FHJ, Mannon RB, Nickerson P, Naesens M. Significance of HLA-DQ in kidney transplantation: time to reevaluate human leukocyte antigen-matching priorities to improve transplant outcomes? An expert review and recommendations. Kidney International 2021;100: 1012-1022
  29. Fewings E, Khoo Sert Kim S, Larionov A, Marker A, Giger O, Shaw A, Clark GR, Kosmoliaptsis V, Challis BG, Tischkowitz M, Casey RT. Investigating the clinical, pathological and molecular profile of oncocytic adrenocortical neoplasms: a case series and literature review. Endocrine Oncology 2021; 1: 33-44
  30. Fiedler S , Piziorska MA, Denninger V, Morgunov AS, Ilsley A, Malik AY, Schneider MM, Devenish SRA, Meisl G, Kosmoliaptsis V, Aguzzi A, Fiegler H, Knowles TPJ. Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum. ACS Infectious Diseases 2021; 9: 2362-2369
  31. Anderton J, Ghobrial M, Kosmoliaptsis V, Casey R. Large adrenal mass heralding the diagnosis of occult extra-adrenal malignancy in two patients. BMJ Case Rep. 2021; 14: e239463
  32. Martin J, Petrillo A, Smyth EC, Shaida N, Khwaja S, Cheow HK, Duckworth A, Heister P, Praseedom R, Jah A, Balakrishnan A, Harper S, Liau S, Kosmoliaptsis V, Huguet E. Colorectal liver mestastases: Current management and future perspectives. World J Clin Oncol. 2020; 11: 761-808
  33. Tambur AR, Campbell P, Chong AS, Feng S, Ford ML, Gebel H, Gill RG, Kelsoe G, Kosmoliaptsis V et al. Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report. American Journal of Transplantation 2020; 20: 2652
  34. Casey RT, McLean MA, Challis BG, McVeigh TP, Warren AY, Mendil L, Houghton R, De Sanctis S, Kosmoliaptsis V, Sandford RN, Gallagher FA, Maher ER. Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans. Clin Cancer Res. 2020; 26: 391
  35. Wiebe C, Kosmoliaptsis V, Pochinco D, Gibson IW, Ho J, Birk PE, Goldberg A, Karpinski M, Shaw J, Rush DN, Nickerson PW. HLA-DR/DQ molecular mismatch: A prognostic biomarker for primary alloimmunity. American Journal of Transplantation 2019; 19:1708
  36. Kramer CSM, Franke-van Dijk MEI, Priddey AJ, Pongrácz T, Gnudi E, Car H, Karahan GE, van Beelen E, Zilvold-van den Oever CCC, Rademaker HJ, de Haan N, Wuhrer M, Kosmoliaptsis V, Parren PWHI, Mulder A, Roelen DL, Claas FHJ, Heidt S. Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor-specific antibodies. HLA. 2019; 94: 415-424
  37. Richards J, Hossain M, Summers D, Slater M, Bartlett M, Kosmoliaptsis V, et al. Surveillance arterioveNous fistulAs using ultRasound (SONAR) trial in haemodialysis patients: a study protocol for a multicentre observational study. BMJ Open. 2019; 9: e031210
  38. Mallon DH, Kling C, Robb M, Ellinghaus E, Bradley JA, Taylor CJ, Kabelitz D, Kosmoliaptsis V. Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential. Journal of Immunology 2018; 201: 3780-3792
  39. Georgiades F, Kosmoliaptsis V, Nicholson ML, Russell NK. Preventing conversion to open surgery during laparoscopic donor nephrectomy complicated by bleeding from the aorta. Clin Transplant. 2019; 33: e13653
  40. Alsughayyir J, Chhabra M, Qureshi MS, Mallik M, Ali JM, Gamper I, Moseley EL, Peacock S, Kosmoliaptsis V, Goddard MJ, Linterman MA, Motallebzadeh R, Pettigrew GJ. Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection. Front Immunol. 2019; 9: 3039
  41. Chhabra M, Alsughayyir J, Qureshi MS, Mallik M, Ali JM, Gamper I, Moseley EL, Peacock S, Kosmoliaptsis V, Goddard MJ, Linterman MA, Motallebzadeh R, Pettigrew GJ. Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury. Front Immunol. 2019; 9: 3038
  42. Copley HC, Elango M, Kosmoliaptsis V. Assessment of HLA immunogenicity; current methods, challenges and opportunities. Curr Opin Organ Transplant. 2018; 23: 477-485
  43. Wiebe C*, Kosmoliaptsis V*, Pochinco D, Taylor C, Nickerson PA. Comparison of HLA molecular mismatch methods to determine HLA immunogenicity. Transplantation 2018; 102: 1338-1343
  44. Watson CJE, Kosmoliaptis V, Pley C, Randle L, Fear C, Crick K, Gimson AE, Allison M, Upponi S, Brias R, Jockmans I, Butler AJ. Observations on the ex situ perfusion of livers for transplantation. American Journal of Transplantation 2018; 18: 2005-2020
  45. Burman A, Watson CJE, Kosmoliaptsis V. Ethylene Glycol Poisoning Should Not Contraindicate Liver Donation. Transplantation Direct 2017; 3: e212
  46. Mah T-J, Mallon DH, Brewster O, Saeb-Parsy K, Butler AJ, Bradley JA, Kosmoliaptsis V. Ureteric complications in recipients of kidneys from donation after circulatory death donors. Clinical Transplantation 2017; 31 (4)
  47. Watson CJ, Kosmoliaptsis V, Randle LV, Gimson AE, Brais R, Klinck JR, Hamed M, Tsyben A, Butler AJ. Normothermic perfusion in the assessment and preservation of declined livers prior to transplantation: hyperoxia and vasoplegia - important lessons from the first 12 cases. Transplantation 2017; 101: 1084
  48. Watson CJ, Randle LV, Kosmoliaptsis V, Gibbs P, Allison M, Butler AJ. 26-hour storage of a declined liver prior to successful transplantation using ex vivo normothermic perfusion. Annals of Surgery 2016; 265: e1-e2
  49. Mallon DH, Kling C, Bradley JA, Taylor CJ, Kabelitz D, Kosmoliaptsis V. Computational scoring system to predict HLA immunogenicity. Lancet 2016; 387 (S1): 68
  50. Taylor CJ, Kosmoliaptsis V, Martin J, Knighton G, Mallon DH, Bradley JA, Peacock S. Technical limitations of the C1q single antigen bead assay to detect complement binding HLA-specific antibodies. Transplantation 2017; 101: 1206
  51. Kosmoliaptsis V, Mallon DH, Chen Y, Bolton EM, Bradley JA, Taylor CJ. Alloantibody responses after renal transplant failure can be better predicted by donor-recipient HLA amino acid sequence and physicochemical disparities than conventional HLA matching. American Journal of Transplantation 2016; 16: 2139
  52. Glover TE, Watson CJ, Gibbs P, Bradley JA, Ntzani EE, Kosmoliaptsis V. Conversion from calcineurin to mammalian target of rapamycin inhibitors in liver transplantation: a meta-analysis of randomised controlled trials. Transplantation 2016; 100: 621-9
  53. Watson CJ, Kosmoliaptsis V, Randle LV, Russell NK, Griffiths W, Davies S, Mergantal H, Butler AJ. Pre-implant Normothermic Liver Perfusion (PiNLiP) of a sub-optimal liver donated after circulatory death. American Journal of Transplantation 2016; 16: 353-7
  54. Maxfield SJ, Taylor CJ, Kosmoliaptsis V, Broecker V, Watson CJ, Bradley JA, Peacock S. Transfer of HLA-specific allosensitisation from a highly sensitised deceased organ donor to the recipients of each kidney. American Journal of Transplantation 2015; 15: 2501-6
  55. Kosmoliaptsis V, Salji M, Bardsley V, Chen Y, Thiru S, Griffiths MH, Copley HC, Saeb Parsy K, Bradley JA, Torpey N, Pettigrew GJ. Baseline donor chronic renal injury confers the same transplant survival disadvantage for DCD and DBD kidneys. American Journal of Transplantation 2015; 15: 754-63
  56. Kosmoliaptsis V, Jöris MM, Mallon1 DH, Lankester AC, von dem Borne PA, Kuball J, Bierings M, Cornelissen JJ, Groenendijk – Sijnke ME, van der Holt B, Bradley JA, Oudshoorn M, van Rood JJ, Taylor CJ, Claas FHJ. Physiochemical disparity of mismatched HLA class I alloantigens and risk of acute graft-versus-host disease following HSCT. Bone Marrow Transplantation 2015; 50: 540-4
  57. Mallon DH, Bradley JA, Winn PJ, Taylor CJ, Kosmoliaptsis V. Three-dimensional structural modelling and calculation of electrostatic potentials of HLA Bw4 and Bw6 epitopes to explain the molecular basis for alloantibody binding: towards predicting HLA antigenicity and immunogenicity. Transplantation 2015; 99: 385-90
  58. Goyette P*, Boucher G*, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva E, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S, International IBD Genetics Consortium, Daly MJ, van Steen K, Duerr RH, Barrett J, McGovern D, Schumm P, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH*, Franke A*, Rioux JD*. High density mapping of the MHC reveals a common role for HLA-DRB1*01:03 in IBD and heterozygous advantage in ulcerative colitis. Nature Genetics 2015; 47: 172-9
  59. Mallon DH, Bradley JA, Taylor CJ, Kosmoliaptsis V. Structural and electrostatic analysis of HLA B-cell epitopes: inference on immunogenicity and prediction of humoral alloresponses. Curr Opin Organ Transplantation 2014; 19: 420-7
  60. Peacock S, Kosmoliaptsis V, Bradley AJ, Taylor CJ. Questioning the Added Value of Luminex Single Antigen Beads to Detect C1q Binding Donor HLA-Specific Antibodies. Transplantation 2014; 98: 384-6
  61. Kosmoliaptsis V, Gjorgjimajkoska O, Sharples LD, Chaudhry AN, Chatzizacharias N, Peacock S, Torpey N, Bolton EM, Taylor CJ, Bradley JA. Impact of donor mismatches at individual HLA-A, -B, -C, -DR and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation. Kidney International 2014; 86: 1039-48
  62. Al Abed YA, Lafferty K, Kosmoliaptsis V. A simple technique for safe mesenteric defect closure following bowel resection. J Surg Tech Case Rep 2012; 4: 22
  63. Kosmoliaptsis V, Dafforn TR, Chaudhry AN, Halsall DJ, Bradley JA, Taylor CJ. High resolution three-dimensional modelling of HLA class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes. Human Immunology 2011; 72: 1049
  64. Hov JR*, Kosmoliaptsis V*, Traherne JA, Olsson M, Boberg KM, Bergquist, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH. Electrostatic modifications of the HLA-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis. Hepatology 2011; 53: 1967
  65. Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL. HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding. Journal of Immunology 2011; 186: 2990
  66. Kosmoliaptsis V, Sharples LD, Chaudhry AN, Halsall DJ, Bradley JA, Taylor CJ. Predicting HLA class II alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms. Transplantation 2011; 91: 183-90
  67. Saeb-Parsy K*, Kosmoliaptsis V*, Sharples LD, Watson CJ, Clatworthy MR, Taylor CJ, Pettigrew GJ, Bradley JA. Donor type does not influence the incidence of major urological complications after kidney transplantation. Transplantation 2010; 90: 1085
  68. Kosmoliaptsis V, Sharples LD, Chaudhry A, Johnson RJ, Fuggle SV, Halsall DJ, Bradley JA, Taylor CJ. HLA class I amino acid sequence-based matching after inter-locus subtraction and long-term outcome after deceased donor kidney transplantation. Hum Immunol 2010; 71: 851-6
  69. Taylor CJ*, Kosmoliaptsis V*, Sharples LD, Prezzi D, Morgan CH, Key T, Chaudhry AN, Amin I, Clatworthy MR, Butler AJ, Watson CJ, Bradley JA. Ten-year experience of selective omission of the pretransplant crossmatch test in deceased donor kidney transplantation. Transplantation 2010; 89: 185
  70. Kosmoliaptsis V, O’Rourke C, Bradley JA, Taylor CJ. Improved Luminex-based human leukocyte antigen-specific antibody screening using dithiothreitol-treated sera. Hum Immunol 2010; 71: 45
  71. Kosmoliaptsis V, Chaudhry AN, Sharples LD, Halsall DJ, Dafforn TR, Bradley JA, Taylor CJ. Predicting HLA class I alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms. Transplantation 2009; 88: 791
  72. Taylor CJ, Kosmoliaptsis V, Summers DM, Bradley JA. Back to the future: application of contemporary technology to long-standing questions about the clinical relevance of human leukocyte antigen-specific alloantibodies in renal transplantation. Hum Immunol 2009; 70: 563
  73. Kosmoliaptsis V, Bradley JA, Taylor CJ. Structural limitations to the mimetic HLA epitope hypothesis. Transplantation 2009; 87: 1262
  74. Kosmoliaptsis V, Bradley JA, Peacock S, Chaudhry A, Taylor CJ. Detection of IgG HLA-specific alloantibodies in renal transplant patients using single-antigen-beads is compromised by the presence of IgM HLA-specific alloantibodies. Transplantation 2009; 87: 813
  75. Riaz AA, Kosmoliaptsis V, Meyrick-Thomas. Laporoscopic Fundoplication: Not a simple wrap. BJMP 2009; 2: 25
  76. Kosmoliaptsis V, Goodman RS, Dafforn TR, Bradley JA, Taylor CJ. Structural implications of platelet endothelial cell adhesion molecule-1 polymorphisms. Transplantation 2008; 86: 484
  77. Kosmoliaptsis V, Bradley JA, Sharples LD, Chaudhry A, Key T, Goodman RS, Taylor CJ. Predicting the immunogenicity of HLA class I alloantigens using structural epitope analysis determined by HLAMatchmaker. Transplantation 2008; 85: 1817
  78. Kosmoliaptsis V, Singhal V, Vohrah A, Dimitri W. Selective Embolotherapy as a Treatment Option for Lower Gastrointestinal Haemorrhage Following Open-Heart Surgery. Interact Cardiovasc Thorac Surg 2007; 6: 558
  79. Kosmoliaptsis V, Soni R. J. Tophaceous gout mass distending the prepatellar bursa. Clin Rheumatol 2007; 13: 359
  80. Kothari MS, Kosmoliaptsis V, Meyrick-Thomas J. Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction. Int Semin Surg Oncol. 2005; 2: 24