Current Reseach
Human Leukocyte Antigen immunogenicity, humoral alloimmunity and immunological risk assessment in transplantation
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Structural analysis of alloantibody-HLA interactions and of HLA B-cell epitopes - We are interested in understanding the structure of immunogenic HLA B-cell epitopes that drive humoral alloimmune responses in transplant recipients and study the molecular basis of alloantibody-HLA interactions. Read more
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Biophysical assessment of HLA-alloantibody interactions and profiling of alloantibody function - We are interested in understanding how alloantibodies mediate their action through their Fab and Fc regions and in developing novel assays to profile their functional properties. Read more
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HLA molecular mismatch algorithms and HLA-related immunological risk - Our lab has pioneered the development of computational algorithms (Cambridge HLA Immunogenicity algorithm and HLA Electrostatic Mismatch Score 3-Dimensional) to predict the immunogenic potential of donor HLA and provided evidence that this approach can be used as a prognostic biomarker of primary alloimmunity. Read more
- Non-invasive assessment of the conditional state of transplant organs - We capitalise on biological samples from transplant patients and from experimental and clinical ex vivo normothermic machine perfusion studies to identify biomarkers of organ quality and to investigate mechanisms of ischaemia-reperfusion injury (IRI) and its effect on graft function. Read more
- Donor organ assessment and reconditioning using ex vivo machine perfusion - Our department has pioneered the development and clinical translation of normothermic machine perfusion as a platform for assessment and reconditioning of donor organs (liver and kidney). Read more